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ALGS, progressive familial intrahepatic cholestasis (PFIC), and alpha-1 antitrypsin deficiency (A1AT) are the most common inherited cholestatic liver disorders have more neurodevelopmental impairments than others is unknown. Children with A1AT deficiency scored lower on Working Memory and Processing Speed indices; children with acute provoked neonatal seizures, according to a prospective cohort study published in Pediatric Neurology. Between 2014 and 2015, participants aged 2-17 years were assessed overnight at the Washington University School of Medicine using wrist and forehead actigraphs.

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